{"id":9819,"date":"2023-12-14T12:56:07","date_gmt":"2023-12-14T11:56:07","guid":{"rendered":"https:\/\/fbhi.devcx.com\/network-project\/j-mint-japan\/"},"modified":"2025-07-16T14:17:32","modified_gmt":"2025-07-16T12:17:32","slug":"j-mint-japan","status":"publish","type":"network-project","link":"https:\/\/fbhi.devcx.com\/sv\/network-project\/j-mint-japan\/","title":{"rendered":"J-MINT (Japan)"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column top_padding_desktop=”0″ bottom_padding_desktop=”0″ left_padding_desktop=”0″ right_padding_desktop=”30″ column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”5px” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”2\/3″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_color=”#006885″ column_border_style=”solid” column_padding_type=”advanced” gradient_type=”default”][vc_column_text css=”.vc_custom_1750946009724{margin-right: 40px !important;padding-top: 1px !important;padding-right: 1px !important;padding-bottom: 1px !important;padding-left: 1px !important;}”]\n

The Japan Multimodal Intervention Trial for Prevention of Dementia (J-MINT)<\/h4>\n[\/vc_column_text][vc_column_text css=”.vc_custom_1750949298602{margin-right: 50px !important;border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;padding-top: 6px !important;padding-right: 6px !important;padding-bottom: 6px !important;padding-left: 7px !important;border-left-color: #e3a883 !important;border-left-style: solid !important;border-right-color: #e3a883 !important;border-right-style: solid !important;border-top-color: #e3a883 !important;border-top-style: solid !important;border-bottom-color: #e3a883 !important;border-bottom-style: solid !important;border-radius: 5px !important;}”]J-MINT is the first large-scale randomized controlled trial in Japan to examine the efficacy of lifestyle interventions to prevent cognitive decline. The trial, launched in 2019, investigates the preventive effects of multidomain interventions in older adults with mild cognitive impairment and a high risk of developing dementia. Evidence from the trial is expected to inform national implementation of multidomain intervention programs and support improvements in dementia prevention, medical standards, the medical economy, and societal services.[\/vc_column_text][divider line_type=”No Line” custom_height=”1″][vc_column_text css=”.vc_custom_1750945815752{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}”]\n

Locations<\/h5>\n[\/vc_column_text][vc_column_text]The study involves five centers in Obu, Nagoya, Toyoake and Tokyo.[\/vc_column_text][divider line_type=”No Line”][vc_column_text css=”.vc_custom_1750945849124{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}”]\n
Organizations and collaborators<\/h5>\n[\/vc_column_text][vc_column_text css=”.vc_custom_1750945831614{margin-right: 50px !important;}”]A multicenter study coordinated by the National Center for Geriatrics and Gerontology (NCGG) with participation from Nagoya University, Nagoya City University, Fujita Health University, and Tokyo Metropolitan Institute for Geriatrics and Gerontology.<\/p>\n

The research team collaborated with private companies in delivering the intervention program. This partnership is expected to facilitate the smooth development of new services and manuals following the intervention trials.[\/vc_column_text][divider line_type=”No Line”][vc_column_text css=”.vc_custom_1750944520112{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}”]\n

Principal Investigator (PI)<\/h5>\n[\/vc_column_text][vc_column_text]Professor Hidenori Arai, National Center for Geriatrics and Gerontology[\/vc_column_text][divider line_type=”No Line”][vc_column_text css=”.vc_custom_1750944556166{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}”]\n
Research team<\/h5>\n[\/vc_column_text][vc_column_text]Co-PI: Takashi Sakurai, National Center for Geriatrics and Gerontology[\/vc_column_text][divider line_type=”No Line”][vc_column_text css=”.vc_custom_1750944671618{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}”]\n
Description<\/h5>\n[\/vc_column_text][vc_column_text]Aim<\/strong>
\nTo examine the efficacy of a multidomain intervention program (management of vascular risk factor, physical exercise, nutritional counselling, cognitive training) in reducing cognitive decline among older adults with mild cognitive impairment. Evidence from the trial is expected to inform a large-scale, national implementation of multidomain intervention programs and support further improvements in dementia prevention strategies, medical standards, the medical economy, and societal services.<\/p>\n

Duration of the intervention<\/strong>
\n18 months<\/p>\n

Current stage of the project<\/strong>
\nComplete<\/p>\n

Target population<\/strong>
\nOlder adults with mild cognitive impairment aged 65-85 years at high risk of developing dementia<\/p>\n

Number of participants<\/strong>
\n531<\/p>\n

Primary outcome<\/strong>
\nChange in composite score of cognitive function by combining several neuropsychological domains.<\/p>\n

Secondary outcomes<\/strong>
\ninclude the related changes in physical function, blood biomarkers, brain morphology observed with neuroimaging, and others.<\/p>\n

Exploratory outcomes<\/strong>
\nCost-effectiveness, factors associated with intervention adherence, identifying populations more likely to benefit from the intervention.<\/p>\n

Acknowledgement to funders and collaborators<\/strong>
\nThese studies are supported by the Japan Agency for Medical Research and Development.[\/vc_column_text][divider line_type=”No Line”][vc_column_text css=”.vc_custom_1750944578157{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}”]\n

Intervention<\/h5>\n[\/vc_column_text][vc_column_text]Domains<\/strong>
\nManagement of vascular risk factors, physical exercise, nutritional counselling, cognitive training.[\/vc_column_text][divider line_type=”No Line”][vc_column_text css=”.vc_custom_1750944596940{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}”]\n
Results<\/h5>\n[\/vc_column_text][vc_column_text css=”.vc_custom_1750950997623{margin-right: 40px !important;}”]Primary outcome<\/strong>
\nNo significant mean difference in the change in composite cognitive score from baseline at the 18-month follow-up between the intervention and control groups (mean difference: 0.047; 95% CI \u22120.029 to 0.124; p = 0.226; Cohen\u2019s d = 0.087).<\/p>\n

Secondary outcome<\/strong>
\nSignificant beneficial effects on dietary diversity, number of participating groups, handicap from hearing loss, body mass index, fat-free mass, and systolic blood pressure values at the 18-month follow-up.<\/p>\n

Sub-analysis<\/strong>
\nThe adherent intervention group (\u226570%) exhibited a significant interventional effect compared to the nonadherent intervention group (mean difference: 0.233; 95% CI 0.079 to 0.388; p = 0.003; Cohen\u2019s d = 0.540) and control group (mean difference: 0.080; 95% CI 0.001 to 0.159; p = 0.047; Cohen\u2019s d = 0.160). A significant interventional effect on the cognitive composite score among older adults with the APOE \u03b54 allele (mean difference: 0.164; 95% CI 0.011 to 0.317; p = 0.035; Cohen\u2019s d = 0.377) and those with GFAP levels of \u2265278.105 pg\/mL (mean difference: 0.231; 95% CI 0.009 to 0.453; p = 0.042; Cohen\u2019s d = 0.428).[\/vc_column_text][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”extra-color-2″ animate=”yes” delay=”1″][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/3″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”No Line” custom_height=”2″][image_with_animation image_url=”8699″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”5px” box_shadow=”none” image_loading=”lazy-load” max_width=”100%” max_width_mobile=”default”][divider line_type=”No Line” custom_height=”1″][vc_column_text css=”.vc_custom_1751039077983{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;padding-top: 5px !important;padding-right: 5px !important;padding-bottom: 5px !important;padding-left: 7px !important;border-left-color: #dd9933 !important;border-left-style: solid !important;border-right-color: #dd9933 !important;border-right-style: solid !important;border-top-color: #dd9933 !important;border-top-style: solid !important;border-bottom-color: #dd9933 !important;border-bottom-style: solid !important;border-radius: 5px !important;}”]Project website
\n<\/strong>Japan-multimodal intervention trial for prevention of dementia(J-MINT)<\/a>
\n(National Center for Geriatrics and Gerontology)<\/p>\n

Protocol<\/strong>
\nThe Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial<\/a>
\n(Springer, 2021)<\/p>\n

Main results
\n<\/strong>Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial<\/a>
\n(Alzheimer’s & Dementia, 2024)<\/p>\n

Exploratory results
\n<\/strong>Factors associated with adherence to tablet-based cognitive training: J-MINT study<\/a>
\n(Alzheimer’s & Dementia, 2025)<\/p>\n

Adherence and aerobic exercise intensity in live online exercise sessions for older adults with mild cognitive impairment: Insights from the Japan-Multimodal Intervention Trial for the Prevention of Dementia<\/span><\/a>
\n(Journal of Aging Research and Lifestyle, 2025)<\/p>\n

A diffusion kurtosis imaging study of the relationship between whole brain microstructure and cognitive function in older adults with mild cognitive impairment <\/a>
\n(Sage Journals, 2024)[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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