{"id":13390,"date":"2025-10-22T13:27:00","date_gmt":"2025-10-22T11:27:00","guid":{"rendered":"https:\/\/fbhi.devcx.com\/network-project\/thisce-taiwan\/"},"modified":"2025-10-27T15:03:28","modified_gmt":"2025-10-27T14:03:28","slug":"thisce-taiwan","status":"publish","type":"network-project","link":"https:\/\/fbhi.devcx.com\/sv\/network-project\/thisce-taiwan\/","title":{"rendered":"THISCE (Taiwan)"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column top_padding_desktop=&#8221;0&#8243; bottom_padding_desktop=&#8221;0&#8243; left_padding_desktop=&#8221;0&#8243; right_padding_desktop=&#8221;30&#8243; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;5px&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;2\/3&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_color=&#8221;#006885&#8243; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;advanced&#8221; gradient_type=&#8221;default&#8221;][vc_column_text css=&#8221;.vc_custom_1761132687680{margin-right: 40px !important;padding-top: 1px !important;padding-right: 1px !important;padding-bottom: 1px !important;padding-left: 1px !important;}&#8221;]\n<h4>Taiwan Health Promotion Intervention Study for Elders (THISCE)<\/h4>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761224492944{margin-right: 50px !important;border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;padding-top: 6px !important;padding-right: 6px !important;padding-bottom: 6px !important;padding-left: 7px !important;border-left-color: #e3a883 !important;border-left-style: solid !important;border-right-color: #e3a883 !important;border-right-style: solid !important;border-top-color: #e3a883 !important;border-top-style: solid !important;border-bottom-color: #e3a883 !important;border-bottom-style: solid !important;border-radius: 5px !important;}&#8221;]<strong>THISCE<\/strong> included two complementary lifestyle intervention-based clinical trials for the prevention of physical and cognitive decline for older adults. The <em>Efficacy Study<\/em> compared effects of a lifestyle-based multidomain intervention with conventional health education. The <em>Empowerment Study<\/em> evaluated the benefit of an enhanced and further empowering intervention program. Study results from both trials show reduction in frailty and improved aspects of physical, functional and cognitive performance, particularly among participants aged 75 and older. Further investigation is recommended to confirm long-term effects.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221986047{margin-right: 50px !important;border-top-width: 1px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;border-left-width: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;border-left-color: #e3a883 !important;border-right-color: #e3a883 !important;border-top-color: #e3a883 !important;border-bottom-color: #e3a883 !important;border-radius: 5px !important;}&#8221;]<em>Latest page update: 23 October, 2025<\/em>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756713428474{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Aim of the project<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221252719{margin-right: 40px !important;}&#8221;]This is a parallel prospective cluster-randomized trial.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221273707{margin-right: 50px !important;}&#8221;]\n<ul>\n<li>Assess the efficacy of a 12-month participatory community-group multidomain intervention against physical and cognitive decline among prefrail\/frail community-dwelling older people (<em>Efficacy Study<\/em>)<\/li>\n<li>Evaluate the benefit of further empowering individual participants (<em>Empowerment Study<\/em>)<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756283848827{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Location<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761220875863{margin-right: 40px !important;}&#8221;]Taipei, Taichung, Kaohsiung, Kinmen and Yilan[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761048107153{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Local setting<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761220920291{margin-right: 50px !important;}&#8221;]The Efficacy Study enrolled participants from 40 clusters (community centers\/neighborhoods with 500\u20131000 residents \u226565 years old) in five cities\/counties across Taiwan: Taipei, Taichung, and Kaohsiung, Yilan, and Kinmen.<\/p>\n<p>The Empowerment Study enrolled a separate cohort of participants, who did not overlap with those in the Efficacy Study, from another 14 clusters in Taipei, Taichung, and Kaohsiung.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756801439111{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Organizations involved<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761132835772{margin-right: 50px !important;}&#8221;]The study is coordinated by the Taipei Veterans General Hospital.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1750944520112{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Principal Investigator (PI)<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761132863366{margin-right: 50px !important;}&#8221;]Liang-Kung Chen, Taipei Veterans General Hospital[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756298026049{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Research team<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221003365{margin-right: 50px !important;}&#8221;]Wei-Ju Lee, Taipei Veterans General Hospital, YuanShan branch<br \/>\nChu-Sheng Lin, Taichung Veterans General Hospital<br \/>\nMing-Yueh Chou, Kaohsiung Veterans General Hospital<br \/>\nChe-Chang Chan, Ministry of Health and Welfare Kinmen Hospital[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761132878363{margin-right: 50px !important;}&#8221;][\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756285820979{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Duration of the intervention<\/h5>\n[\/vc_column_text][vc_column_text]12 months[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756305270248{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Project start date<\/h5>\n[\/vc_column_text][vc_column_text]2014[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756305197166{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Project end date<\/h5>\n[\/vc_column_text][vc_column_text]2017[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286177804{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Current stage of the project<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1760964015793{margin-right: 70px !important;border-radius: 5px !important;}&#8221;]Complete[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286650835{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Number of study participants<\/h5>\n[\/vc_column_text][vc_column_text]\n<ul>\n<li>1082 participants in the Efficacy study<\/li>\n<li>440 participants in the Empowerment study<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286716985{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Target population<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221328104{margin-right: 50px !important;}&#8221;]Community-dwelling older adults aged above 65 years with subjective memory impairment and prefrail\/frail[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1760970121836{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Outcomes<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1760972145303{margin-right: 60px !important;margin-bottom: 2px !important;}&#8221;]<strong>Primary outcomes<\/strong>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761132994272{margin-right: 60px !important;margin-bottom: 25px !important;}&#8221;]\n<ul>\n<li>Changes in cognitive performance (MoCA<sub>adj<\/sub>)<\/li>\n<li>Changes in frailty status<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761133010556{margin-right: 60px !important;margin-bottom: 2px !important;}&#8221;]<strong>Secondary outcomes<\/strong>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761133032891{margin-right: 60px !important;margin-bottom: 25px !important;}&#8221;]\n<ul>\n<li>Functional capacity<\/li>\n<li>Nutritional status<\/li>\n<li>Depressive symptoms<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1750944578157{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Intervention<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221404521{margin-right: 50px !important;}&#8221;]The Efficacy Study compared the effect of multidomain intervention over 12 months with conventional health education.<\/p>\n<p>The Empowerment Study compared implementing the same standard multidomain intervention as was used in the Efficacy Study for 6 months, vs. an enhanced version of that programme (months 6 to 12), with post-intervention follow-up at 9 months.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761133129956{margin-right: 50px !important;}&#8221;]<strong>Domains<\/strong>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761133158791{margin-right: 50px !important;}&#8221;]\n<ul>\n<li>Physical exercise<\/li>\n<li>Cognitive training<\/li>\n<li>Nutritional counselling<\/li>\n<\/ul>\n[\/vc_column_text][divider line_type=&#8221;Small Line&#8221; line_alignment=&#8221;default&#8221; line_thickness=&#8221;1&#8243; divider_color=&#8221;extra-color-2&#8243;][vc_column_text css=&#8221;.vc_custom_1761221454699{margin-right: 50px !important;}&#8221;]\n<ul>\n<li>Healthy nutrition education based on Taiwan HPA dietary guidelines<\/li>\n<li>For the second half of the Empowerment Study, the training sessions used new teaching materials, revised and simplified from the standard multidomain prototype, which addressed feedback from a needs-assessment survey in local communities. Participants were also given a pedometer and post-curriculum learning sheets to support goal setting and monitoring and additionally empowered by community leader involvement, group competitions, and individual motivation. <\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756715921870{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Results<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761138597073{margin-right: 60px !important;margin-bottom: 20px !important;}&#8221;]<strong>Primary outcomes<\/strong>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761138726037{margin-right: 60px !important;}&#8221;]<em>Efficacy study<\/em>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221484194{margin-right: 60px !important;}&#8221;]\n<ul>\n<li>No differences in change in frailty status when comparing intervention and control group.<\/li>\n<li>No difference in physical and cognitive function.<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761136720218{margin-right: 60px !important;}&#8221;]<em>Empowerment study<\/em>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221506948{margin-right: 60px !important;}&#8221;]\n<ul>\n<li>Improved cognitive performance at 9 months in the enhanced intervention group compared to the standard multidomain intervention<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761138718590{margin-right: 60px !important;}&#8221;]<strong>Secondary outcomes<\/strong>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761138421393{margin-right: 60px !important;margin-bottom: 20px !important;}&#8221;]<em>Efficacy study<\/em>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221538468{margin-right: 60px !important;}&#8221;]\n<ul>\n<li>At 6 months concentration improved when comparing intervention vs control group<\/li>\n<li>At 12 months, participants in the intervention group were less likely to report depressive symptoms and have malnutrition compared to the control group.<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761136720218{margin-right: 60px !important;}&#8221;]<em>Empowerment study<\/em>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221584708{margin-right: 60px !important;}&#8221;]\n<ul>\n<li>At 6 months, improved gait speed and physical activity in the enhanced intervention group compared to the standard multidomain intervention<\/li>\n<li>At 9 months, participants in the enhanced intervention group improved delayed recall, were less likely to report depressive symptoms and be malnourished compared to the standard multidomain intervention.<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761136859079{margin-right: 60px !important;margin-bottom: 2px !important;}&#8221;]<strong>Sub-analysis<\/strong>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221609139{margin-right: 60px !important;}&#8221;]Both the standard and enhanced multidomain interventions significantly improved cognitive performance among \u226575-year-olds, with a sustained gain 3 months after the participant-empowered intervention ceased.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761136939300{margin-right: 60px !important;}&#8221;]<em>In the efficacy study<\/em>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221646280{margin-right: 60px !important;}&#8221;]\n<ul>\n<li>Participants above the age of 75 in the intervention group had lower frailty scores, reported fewer depressive symptoms and improved delayed recall and cognition at 12 months compared to the control group.<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761136961731{margin-right: 60px !important;}&#8221;]<em>In the empowerment study<\/em>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221685019{margin-right: 60px !important;}&#8221;]\n<ul>\n<li>Participants above the age of 75 in the enhanced intervention had lower frailty scores at 6 months and improved their physical activity and functional ability at 6 and 9 months compared to the control group.<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221713280{margin-right: 60px !important;}&#8221;]This study showed that participants \u226575 years old had even greater improvements in their physical and mental performance than younger ones, including significantly diminished prevalence of frailty during the intervention.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756304280464{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Acknowledgements<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1761221751209{margin-right: 60px !important;}&#8221;]The Taiwan Health Promotion Intervention Study for Elders was funded by the Health Promotion Administration, Ministry of Health and Welfare, Taiwan (MOHW105-HPA-H-124-144101).[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756284734132{margin-right: 40px !important;}&#8221;][\/vc_column_text][\/vc_column][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/3&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][divider line_type=&#8221;No Line&#8221;][image_with_animation image_url=&#8221;13370&#8243; image_size=&#8221;full&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; alignment=&#8221;&#8221; border_radius=&#8221;5px&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;lazy-load&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221;][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;1&#8243;][vc_column_text css=&#8221;.vc_custom_1761221890072{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;padding-top: 5px !important;padding-right: 5px !important;padding-bottom: 5px !important;padding-left: 7px !important;border-left-color: #dd9933 !important;border-left-style: solid !important;border-right-color: #dd9933 !important;border-right-style: solid !important;border-top-color: #dd9933 !important;border-top-style: solid !important;border-bottom-color: #dd9933 !important;border-bottom-style: solid !important;border-radius: 5px !important;}&#8221;]<strong>Results<br \/>\n<\/strong><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12534\" target=\"_blank\" rel=\"noopener\">Efficacy of multidomain interventions to improve physical frailty, depression and cognition: data from cluster-randomized controlled trials<\/a><br \/>\n(Journal of Cachexia, Sarcopenia and Muscle, 2020)<\/p>\n<p id=\"screen-reader-main-title\" class=\"Head u-font-serif u-h2 u-margin-s-ver\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167494321000546?via%3Dihub\" target=\"_blank\" rel=\"noopener\"><span class=\"title-text\">Efficacy of Multidomain Intervention Against Physio-cognitive Decline Syndrome: A Cluster-randomized Trial<\/span><\/a><br \/>\n(Archives of Gerontology and Geriatrics, 2021)<\/p>\n<p class=\"heading-title\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38374742\/\" target=\"_blank\" rel=\"noopener\">Roles of Baseline Intrinsic Capacity and its Subdomains on the Overall Efficacy of Multidomain Intervention in Promoting Healthy Aging among Community-Dwelling Older Adults: Analysis from a Nationwide Cluster-Randomized Controlled Trial <\/a><br \/>\n(The Journal of Prevention of Alzheimer&#8217;s disease, 2024)<\/p>\n[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>A pragmatic multidomain intervention can diminish physical frailty, malnutrition, and depression and enhance cognitive performance.<\/p>\n","protected":false},"featured_media":13371,"template":"","class_list":["post-13390","network-project","type-network-project","status-publish","has-post-thumbnail","network-project-category-completed-sv"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"A pragmatic multidomain intervention can diminish physical frailty, malnutrition, and depression and enhance cognitive performance.\" \/>\n\t<meta name=\"robots\" content=\"noindex, nofollow, max-image-preview:large\" \/>\n\t<link rel=\"canonical\" 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