{"id":13110,"date":"2025-08-27T10:28:25","date_gmt":"2025-08-27T08:28:25","guid":{"rendered":"https:\/\/fbhi.devcx.com\/network-project\/hun-mli-brain-hungary\/"},"modified":"2025-09-01T15:01:42","modified_gmt":"2025-09-01T13:01:42","slug":"hun-mli-brain-hungary","status":"publish","type":"network-project","link":"https:\/\/fbhi.devcx.com\/sv\/network-project\/hun-mli-brain-hungary\/","title":{"rendered":"HUN-MLI-BRAIN (Hungary)"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column top_padding_desktop=&#8221;0&#8243; bottom_padding_desktop=&#8221;0&#8243; left_padding_desktop=&#8221;0&#8243; right_padding_desktop=&#8221;30&#8243; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;5px&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;2\/3&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_color=&#8221;#006885&#8243; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;advanced&#8221; gradient_type=&#8221;default&#8221;][vc_column_text css=&#8221;.vc_custom_1756283507057{margin-right: 40px !important;padding-top: 1px !important;padding-right: 1px !important;padding-bottom: 1px !important;padding-left: 1px !important;}&#8221;]\n<h4>The Effects of a Hungarian Multidomain Lifestyle Intervention on Brain Health in Older Adults (HUN-MLI-BRAIN)<\/h4>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756296723803{margin-right: 50px !important;border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;padding-top: 6px !important;padding-right: 6px !important;padding-bottom: 6px !important;padding-left: 7px !important;border-left-color: #e3a883 !important;border-left-style: solid !important;border-right-color: #e3a883 !important;border-right-style: solid !important;border-top-color: #e3a883 !important;border-top-style: solid !important;border-bottom-color: #e3a883 !important;border-bottom-style: solid !important;border-radius: 5px !important;}&#8221;]The <strong>HUN-MLI-BRAIN<\/strong> randomized controlled trial investigates the impact of a Hungarian lifestyle intervention on brain health in older adults, and is based on <a href=\"https:\/\/fbhi.devcx.com\/the-finger-stud\" target=\"_blank\" rel=\"noopener\">FINGER<\/a>. The study aims to maintain and enhance neurocognitive function in older adults through a lifestyle program in which traditional folk dance plays an important role, along with interventions focused on diet, physical and cognitive activity, social engagement, and monitoring of cardiovascular health. The use of advanced, precision neuroimaging techniques will offer novel insights into changes in brain networks, and inform the development of effective, personalized interventions for prevention of cognitive decline.[\/vc_column_text][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;1&#8243;][vc_column_text css=&#8221;.vc_custom_1756283848827{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Location<\/h5>\n[\/vc_column_text][vc_column_text]Budapest, Hungary[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1750945849124{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Organizations and collaborators<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756291039264{margin-right: 50px !important;}&#8221;]The HUN-REN Research Centre for Natural Sciences in collaboration with the HUN-REN Institute of Experimental Medicine and the Semmelweis University[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1750944520112{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Principal Investigator (PI)<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756302544828{margin-right: 50px !important;}&#8221;]Zolt\u00e1n Vidny\u00e1nszky, Brain Imaging Centre, HUN-REN Research Centre for Natural Sciences[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756300927647{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Research team<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756301019510{margin-right: 50px !important;}&#8221;]Kitti B\u00e1n, Petra Hermann, Fanni De\u00e1k, P\u00e1l Vakli, Attila Keresztes, Petra Madurka, Katalin \u0150ry-Kov\u00e1cs, <em>Brain Imaging Centre, HUN-REN Research Centre for Natural Sciences<\/em><\/p>\n<p>Tibor Kov\u00e1cs, <em>Semmelweis University<\/em><\/p>\n<p>\u00c1d\u00e1m D\u00e9nes, <em>HUN-REN Institute of Experimental Medicine<\/em>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756285788727{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Aim of the project<\/h5>\n[\/vc_column_text][vc_column_text]This randomized controlled study aims to maintain and enhance neurocognitive function and prevent cognitive decline in older adults through a multi-domain lifestyle program, which simultaneously targets dietary habits, physical and cognitive activity, and social engagement.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756285820979{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Duration of the intervention<\/h5>\n[\/vc_column_text][vc_column_text]6 months[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286037216{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Start date<\/h5>\n[\/vc_column_text][vc_column_text]2024[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286101518{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>End date<\/h5>\n[\/vc_column_text][vc_column_text]2027[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286177804{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Current stage of the project<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756295638675{margin-right: 700px !important;border-radius: 5px !important;}&#8221;]Ongoing[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286650835{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Number of study participants<\/h5>\n[\/vc_column_text][vc_column_text]80 (estimated)[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286716985{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Target population<\/h5>\n[\/vc_column_text][vc_column_text]Community-dwelling older adults aged 65 to 75 years[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286809880{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Primary outcome<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756301119510{margin-right: 60px !important;}&#8221;]\n<ul>\n<li>Brain functional connectivity measured with resting-state fMRI<\/li>\n<li>Brain function measured with resting-state EEG<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756288801479{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Secondary outcome<\/h5>\n[\/vc_column_text][vc_column_text]\n<ul>\n<li>Brain Reward System resting-state fMRI connectivity<\/li>\n<li>Brain&#8217;s Default Mode Network resting-state fMRI connectivity<\/li>\n<li>Brain Age (estimated using T1-weighted MRI images)<\/li>\n<li>Volume of hippocampal subfields<\/li>\n<li>Striatal volume<\/li>\n<li>Volume of neuromodulatory nuclei (substantia nigra\/ventral tegmental area, locus coeruleus)<\/li>\n<li>Resting-state EEG frequency band measures (alpha, beta)<\/li>\n<li>Subjective cost of cognitive effort<\/li>\n<li>Global cognitive function (Verbal Episodic Memory Test, Location Learning Test, digit span, verbal fluency, Trail Making Test, Victoria Stroop test, Digit Symbol Substitution Test)<\/li>\n<li>Blood biomarkers (inflammatory cytokines, C-reactive protein, glial fibrillary acidic protein, clustering, brain derived neurotrophic factor, insulin growth factor-1)<\/li>\n<li>Anthropometric and metabolic measures (waist circumference, BMI, systolic &amp; diastolic blood pressure)<\/li>\n<li>Hand grip strength<\/li>\n<li>Physical performance (self-reported, Short Physical Performance Battery, tracked via Polar Pacer smart watch)<\/li>\n<li>Sleep (Athens Insomnia Scale, Pittsburgh Sleep Quality Index, tracked via Polar Pacer smart watch)<\/li>\n<li>Depressive symptoms (Geriatric Depression Scale, Patient Health Questionnaire)<\/li>\n<li>Well-being (WHO Well-being Questionnaire)<\/li>\n<li>Social support (Multidimensional Scale of Perceived Social Support)<\/li>\n<li>Sarcopenia (SARC-F questionnaire)<\/li>\n<li>Dementia risk score (CAIDE)<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1750944578157{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Intervention<\/h5>\n[\/vc_column_text][vc_column_text]<strong>Study arms<\/strong>[\/vc_column_text][vc_column_text]\n<ul>\n<li>Simultaneous physical, cognitive, and social multidomain training integrated in folk dance intervention<\/li>\n<li>Self-guided multidomain intervention<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756302401771{margin-left: 50px !important;}&#8221;]<strong><span style=\"color: #000000;\">\u2514<\/span> Domains of the Folk dance multidomain intervention<br \/>\n<\/strong>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756301964000{margin-left: 50px !important;}&#8221;]\n<ul>\n<li>Physical exercise<\/li>\n<li>Mental stimulation<\/li>\n<li>Social interaction<\/li>\n<li>Monitoring of cardiovascular and metabolic risk factors<\/li>\n<li>Diet<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1750944596940{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Results<\/h5>\n[\/vc_column_text][vc_column_text]No results have been published yet.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756284734132{margin-right: 40px !important;}&#8221;][\/vc_column_text][\/vc_column][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/3&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][divider line_type=&#8221;No Line&#8221;][image_with_animation image_url=&#8221;12952&#8243; image_size=&#8221;full&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; alignment=&#8221;&#8221; border_radius=&#8221;5px&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;lazy-load&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221;][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;1&#8243;][vc_column_text css=&#8221;.vc_custom_1756285326154{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;padding-top: 5px !important;padding-right: 5px !important;padding-bottom: 5px !important;padding-left: 7px !important;border-left-color: #dd9933 !important;border-left-style: solid !important;border-right-color: #dd9933 !important;border-right-style: solid !important;border-top-color: #dd9933 !important;border-top-style: solid !important;border-bottom-color: #dd9933 !important;border-bottom-style: solid !important;border-radius: 5px !important;}&#8221;]<strong>Registered trial<br \/>\n<\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06616285\" target=\"_blank\" rel=\"noopener\">The Effects of a Hungarian Multidomain Lifestyle Intervention on Brain Health in Older Adults (HUN-MLI-BRAIN)<\/a>[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column 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