{"id":13013,"date":"2025-08-28T17:07:00","date_gmt":"2025-08-28T15:07:00","guid":{"rendered":"https:\/\/fbhi.devcx.com\/network-project\/ginger-greece-2\/"},"modified":"2026-03-13T02:22:45","modified_gmt":"2026-03-13T01:22:45","slug":"agewell-de","status":"publish","type":"network-project","link":"https:\/\/fbhi.devcx.com\/sv\/network-project\/agewell-de\/","title":{"rendered":"AgeWell.de (Germany)"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column top_padding_desktop=&#8221;0&#8243; bottom_padding_desktop=&#8221;0&#8243; left_padding_desktop=&#8221;0&#8243; right_padding_desktop=&#8221;30&#8243; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;5px&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;2\/3&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_color=&#8221;#006885&#8243; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;advanced&#8221; gradient_type=&#8221;default&#8221;][vc_column_text css=&#8221;.vc_custom_1756393831895{margin-right: 40px !important;padding-top: 1px !important;padding-right: 1px !important;padding-bottom: 1px !important;padding-left: 1px !important;}&#8221;]\n<h4>AgeWell.de<\/h4>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756402247892{margin-right: 50px !important;border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;padding-top: 6px !important;padding-right: 6px !important;padding-bottom: 6px !important;padding-left: 7px !important;border-left-color: #e3a883 !important;border-left-style: solid !important;border-right-color: #e3a883 !important;border-right-style: solid !important;border-top-color: #e3a883 !important;border-top-style: solid !important;border-bottom-color: #e3a883 !important;border-bottom-style: solid !important;border-radius: 5px !important;}&#8221;]\n<section id=\"alz14097-sec-0040\">The AgeWell.de trial is the first multi-component trial targeting risk of cognitive decline in older adults in Germany. Results show that the intervention reduced dementia risk according to LIBRA scores (LIfestyle for BRAin health), with beneficial effects primarily referable to changes in diet and blood pressure. The intervention improved health-related quality of life in men and women, and reduced depressive symptoms in women. The results support the need of more intensive and better individually targeted lifestyle interventions for older adults.<\/section>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394704480{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Aims of the project<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394690069{margin-right: 50px !important;}&#8221;]\n<ul>\n<li>To evaluate the effectiveness of a multi-component intervention in preventing or delaying cognitive decline in older adults at increased risk for dementia, specifically tailored to the German health care context.<\/li>\n<li>To assess effects of the multi-component intervention regarding (i) mortality, (ii) nursing home placement, (iii) functioning in everyday activities, (iv) quality of life, (v) depressive symptoms, (vi) social inclusion, and (vii) the cost-effectiveness of the intervention<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756283848827{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Location<\/h5>\n[\/vc_column_text][vc_column_text]<strong>Multiple centers<br \/>\n<\/strong><em>Recruiting centers:<\/em> Leipzig, Greifswald, Kiel, Munich, Halle<br \/>\n<em>Expertise centers (no recruitment):<\/em> Hannover (data management), Hamburg (health economics), Heidelberg (pharmacology)[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756297816087{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Local setting<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394110939{margin-right: 50px !important;}&#8221;]<strong>Challenges<br \/>\n<\/strong>The COVID-19 pandemic imposed severe challenges on intervention conduct and extended the duration between baseline and 24-month follow-up interview for a substantial proportion of participants.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394056752{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Leading organization<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394065450{margin-right: 50px !important;}&#8221;]University of Leipzig[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1750944520112{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Principal Investigator (PI)<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394122786{margin-right: 50px !important;}&#8221;]Steffi G. Riedel-Heller, Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756298026049{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Research team<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756712969710{margin-right: 50px !important;}&#8221;]Andrea Z\u00fclke, Alexander Pabst, Melanie Luppa, Steffi G. Riedel-Heller, <em>Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany<\/em><\/p>\n<p>Wolfgang Hoffmann, Jochen Ren\u00e9 Thyrian,\u00a0<em>German Centre for Neurodegenerative Diseases (DZNE), Greifswald, Germany<\/em><\/p>\n<p>Hanna Kaduszkiewicz, <em>Institute of General Practice, University of Kiel, Kiel, Germany<\/em><\/p>\n<p>Jochen Gensichen, <em>Institute of General Practice and Family Medicine, University Hospital, LMU Munich, Munich, Germany<\/em><\/p>\n<p>Thomas Frese, <em>Institute of General Practice and Family Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany<\/em><\/p>\n<p>Birgitt Wiese, <em>MHH Information Technology \u2013 Science &amp; Laboratory, Hannover Medical School, Hannover, Germany<\/em><\/p>\n<p>Hans-Helmut K\u00f6nig, <em>Department of Health Economics and Health Service Research, University Medical Centre Hamburg-Eppendorf, Hamburg, Hamburg, Germany<\/em><\/p>\n<p>David Czock, <em>Internal Medicine IX \u2013 Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany<\/em>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756285820979{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Duration of the intervention<\/h5>\n[\/vc_column_text][vc_column_text]24 months[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756305270248{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Project start date<\/h5>\n[\/vc_column_text][vc_column_text]2018[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756305197166{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Project end date<\/h5>\n[\/vc_column_text][vc_column_text]2022[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286177804{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Current stage of the project<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394756642{margin-right: 700px !important;border-radius: 5px !important;}&#8221;]Completed[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286650835{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Number of study participants<\/h5>\n[\/vc_column_text][vc_column_text]819[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756286716985{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Target population<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394829912{margin-right: 50px !important;}&#8221;]Community-dwelling patients from General Practice (primary care), 60-77 years of age and at-risk of dementia (based on CAIDE Dementia Risk Score)[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394875535{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Primary outcome<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394889097{margin-right: 60px !important;}&#8221;]Change in cognitive performance assessed with a neuropsychological test battery (Trail Making Test A and B, CERAD Wordlist Memory, Verbal Fluency Test \u201cAnimals\u201d, CERAD Constructional Practice, Reading the Mind in the Eyes test (revised version)).[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394999258{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Secondary outcomes<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394949313{margin-right: 60px !important;}&#8221;]\n<ul>\n<li>Mortality<\/li>\n<li>Nursing home placement<\/li>\n<li>Instrumental activities of daily living (IADL)<\/li>\n<li>Quality of life<\/li>\n<li>Depressive symptoms<\/li>\n<li>Social inclusion<\/li>\n<li>Motivation for behavior change<\/li>\n<li>Cost-effectiveness<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756394988508{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Exploratory outcomes<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756395043712{margin-right: 60px !important;}&#8221;]\n<ul>\n<li>Dementia risk profiles (Lifestyle for Brain Health (LIBRA)-score)<\/li>\n<li>Neuroimaging markers of neurodegeneration and small vessel disease (MRI sub-study at Leipzig study centre)<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1750944578157{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Intervention<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756466825382{margin-top: 10px !important;}&#8221;]<strong>Domains<\/strong>[\/vc_column_text][vc_column_text]\n<ul>\n<li>Nutritional counselling (based on guidelines of the German Nutrition Society)<\/li>\n<li>Physical activity enhancement<\/li>\n<li>Cognitive training: utilized \u201cNeuroNation\u201d software<\/li>\n<li>Optimization of medication<\/li>\n<li>Management of vascular risk factors<\/li>\n<li>Enhancement of social engagement<\/li>\n<li>Intervention for bereavement, grief and depressive symptoms<\/li>\n<\/ul>\n<p>Motivation tasks across all components.[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1750944596940{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Results<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756466840663{margin-top: 10px !important;}&#8221;]<strong>Primary outcome<\/strong>[\/vc_column_text][vc_column_text]\n<ul>\n<li>No intervention effect on the global cognitive performance of individuals in the intervention group.<\/li>\n<li>Intervention effect on dementia risk profiles, assessed using the Lifestyle for Brain Health (LIBRA)-score<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text]<strong>Secondary outcomes<\/strong>[\/vc_column_text][vc_column_text]\n<ul>\n<li>The intervention improved health-related quality of life in the intervention group.<\/li>\n<li>Reduced depressive symptoms in women in the intervention group.<\/li>\n<li>Perceived restrictions in intervention conduct by the COVID-19 pandemic did not impact intervention effectiveness.<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text]<strong>Exploratory outcomes<\/strong>[\/vc_column_text][vc_column_text]\n<ul>\n<li>No intervention effects on neuroimaging markers of neurodegeneration and small vessel disease<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756304280464{margin-right: 50px !important;padding-top: 1px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 1px !important;background-color: rgba(227,168,131,0.52) !important;*background-color: rgb(227,168,131) !important;border-radius: 4px !important;}&#8221;]\n<h5>Acknowledgements<\/h5>\n[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756395657567{margin-right: 60px !important;}&#8221;]This study is funded by the German Federal Ministry for Education and Research (BMBF; reference numbers: 01GL1704A, 01GL1704B, 01GL1704C, 01GL1704D, 01GL1704E, 01GL1704F).[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1756284734132{margin-right: 40px !important;}&#8221;][\/vc_column_text][\/vc_column][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/3&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][image_with_animation image_url=&#8221;13017&#8243; image_size=&#8221;full&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; alignment=&#8221;&#8221; border_radius=&#8221;5px&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;lazy-load&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221;][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;1&#8243;][vc_column_text css=&#8221;.vc_custom_1756713002314{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;padding-top: 5px !important;padding-right: 5px !important;padding-bottom: 5px !important;padding-left: 7px !important;border-left-color: #dd9933 !important;border-left-style: solid !important;border-right-color: #dd9933 !important;border-right-style: solid !important;border-top-color: #dd9933 !important;border-top-style: solid !important;border-bottom-color: #dd9933 !important;border-bottom-style: solid !important;border-radius: 5px !important;}&#8221;]<strong>Study protocol<br \/>\n<\/strong><a href=\"https:\/\/doi.org\/10.1186\/s12877-019-1212-1\" target=\"_blank\" rel=\"noopener\"><i>AgeWell.de<\/i> \u2013 study protocol of a pragmatic multi-center cluster-randomized controlled prevention trial against cognitive decline in older primary care patients<\/a> (BMC Geriatrics, 2019)<\/p>\n<p><strong>Results<br \/>\n<\/strong><\/p>\n<p class=\"title hypothesis_container\"><a href=\"https:\/\/www.mdpi.com\/1660-4601\/18\/2\/408\" target=\"_blank\" rel=\"noopener\">Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study\u2014A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline<\/a> (International Journal of Environmental Research and Public Health, 2021)<\/p>\n<p class=\"citation__title\"><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.13486\" target=\"_blank\" rel=\"noopener\">A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial<\/a>\u00a0(Alzheimer&#8217;s &amp; Dementia, 2023)<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1002\/alz.14097\" target=\"_blank\" rel=\"noopener\">Effects of a multidomain intervention against cognitive decline on dementia risk profiles \u2014 Results from the AgeWell.de trial<\/a>\u00a0(Alzheimer&#8217;s &amp; Dementia, 2024)<\/p>\n<p><a href=\"https:\/\/doi.org\/10.3389\/fpubh.2023.1141433\" target=\"_blank\" rel=\"noopener\">COVID-19 government measures and their impact on mental health: a cross-sectional study of older primary care patients in Germany<\/a> (Public Health, 2023)<\/p>\n<p class=\"c-article-title\" data-test=\"article-title\"><a href=\"https:\/\/alzres.biomedcentral.com\/articles\/10.1186\/s13195-024-01499-4\" target=\"_blank\" rel=\"noopener\">Adherence to a lifestyle intervention \u2013 just a question of self-efficacy? Analysis of the AgeWell.de-intervention against cognitive decline<\/a> (Alzheimer&#8217;s Research &amp; Therapy, 2024)<\/p>\n<p><span class=\"title-text\"><a href=\"https:\/\/doi.org\/10.14283\/jpad.2024.13\" target=\"_blank\" rel=\"noopener\">Who Benefited the Most? Effectiveness of a Lifestyle Intervention Against Cognitive Decline in Older Women and Men \u2013 Secondary Analysis of the AgeWell.de-trial<\/a> (Journal of Prevention of Alzheimer&#8217;s Disease, 2024)<\/span><\/p>\n<p class=\"c-article-title\" data-test=\"article-title\"><a href=\"https:\/\/doi.org\/10.1186\/s12875-024-02566-3\" target=\"_blank\" rel=\"noopener\">General practitioners\u2019 perspectives on lifestyle interventions for cognitive preservation in dementia prevention<\/a> (BMC Primary Care, 2024)<\/p>\n<p><a href=\"https:\/\/doi.org\/10.3389\/fpubh.2024.1435945\" target=\"_blank\" rel=\"noopener\">Social participation and cognitive activities as explanation factor for the association between income and self-rated health for older adult<\/a> (Public Health, 2024)<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.nicl.2025.103796\" target=\"_blank\" rel=\"noopener\">Exploring the effect of multi-modal intervention against cognitive decline on atrophy and small vessel disease imaging markers in the AgeWell.de imaging study<\/a> (NeuroImage: Clinical, 2025)<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1177\/13872877251330296\" target=\"_blank\" rel=\"noopener\">Factors associated with a healthy diet and willingness to change dietary behavior in older adults at increased risk of dementia<\/a>\u00a0(Journal of Alzheimer&#8217;s Disease, 2025)<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1080\/13607863.2024.2394591\" target=\"_blank\" rel=\"noopener\">Potential for reducing dementia risk: association of the CAIDE score with additional lifestyle components from the LIBRA score in a population at high risk of dementia<\/a> (Aging and Mental Health, 2025)<\/p>\n<p class=\"c-article-title\" data-test=\"article-title\"><a href=\"https:\/\/doi.org\/10.1007\/s00394-024-03563-z\" target=\"_blank\" rel=\"noopener\">Dietary changes following a lifestyle-based intervention for dementia risk reduction \u2013 results from the AgeWell.de study<\/a> (European Journal of Nutrition, 2025)<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1177\/13872877251314892\" target=\"_blank\" rel=\"noopener\">Adherence to intervention components: The key to success? Analysis on health-related outcomes of the AgeWell.de intervention to preserve cognition<\/a> (Journal of Alzheimer&#8217;s Disease, 2025)<\/p>\n<p class=\"c-article-title\" data-test=\"article-title\"><a href=\"https:\/\/doi.org\/10.1186\/s12875-025-02948-\" target=\"_blank\" rel=\"noopener\">Two sides of the same coin: recruitment performance and perceived workload in primary care trials-insights from the AgeWell.de study<\/a> (BMC Primary Care, 2025)<\/p>\n<p class=\"citation__title\"><a href=\"https:\/\/doi.org\/10.1002\/trc2.700\" target=\"_blank\" rel=\"noopener\">Cost-effectiveness of a multicomponent intervention against cognitive decline<\/a><br \/>\n(Alzheimer&#8217;s &amp; Dementia: Translational Research &amp; Clinical Interventions, 2025)<\/p>\n[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>Tested a multicomponent intervention in older adults in Germany with increased dementia risk. <\/p>\n","protected":false},"featured_media":13017,"template":"","class_list":["post-13013","network-project","type-network-project","status-publish","has-post-thumbnail","network-project-category-completed-sv"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - 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